US 2026/0250362 A1 · ANTIBODIES AGAINST ORTHOHANTAVIRUSES

Antibodies against orthohantaviruses

AssigneesMapp Biopharmaceutical, Inc., Albert Einstein College of Medicine, Adimab, LLC, Institut Pasteur, University of New Mexico, The Government of the United States, as represented by the Secretary of the Army

InventorsClas AHLM, Mattias FORSELL, Laura M. WALKER, Anna Z. WEC, Pablo GUARDADO-CALVO, Felix A. REY, Eva MITTLER, Kartik CHANDRAN, Steven B. BRADFUTE, Dafna M. ABELSON, Andrew S. Herbert, John DYE

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Abstract

Provided herein are hantivirus antibodies. These hantivirus antibodies bind to the Gn and/or Gc subunits of a hantavirus glycoprotein and have broad neutralizing activity against an epitope of different hantavirus species. Such antibodies are used in methods of inducing an immune response and methods of inhibiting hantavirus infection. Additionally provided are methods of treating an infectious disease using such antibodies.

Claims27

Dependent claims

An isolated antibody that binds to a spike protein of a hantavirus.

Dependencies are inferred from the claim text.