Compounds for positive modulation of the autophagy-lysosomal pathway and methods of use

A compound having a structure of Formula (I) or Formula (II):

• wherein:
• n is 0, 1, 2, 3, 4, 5, or 6;
• each is independently a double or single bond;
• X1 is O or methylene;
• X2 is H, OH, SH, NH2, O, S, or NH, subject to the proviso that when the to which X2 is attached is a single bond, X2 is selected from H, OH, SH, and NH2 and when the to which X2 is attached is a double bond, X2 is O, S or NH;
• X3 is CH or N;
• R1, R2, and R3 are independently selected from the group comprising H, OH, alkyl, substituted alkyl, alkoxy, aralkyl, substituted aralkyl, aryl, and substituted aryl;
• R4 is OH or O, subject to the proviso that R4 is OH when the to which R4 is attached is a single bond and O when the to which R4 is attached is a double bond;
• and
• R5 is selected from H, OH, alkyl, substituted alkyl, aralkyl, substituted aralkyl, aryl, substituted aryl, and N(R6)2, wherein each R6 is independently selected from H, acyl, alkyl, substituted alkyl, aralkyl, substituted aralkyl, aryl, and substituted aryl, or wherein the two R6 together form a substituted or unsubstituted alkylene or aralkylene group;
• or
• a pharmaceutically acceptable salt thereof.