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AssigneeBoston Scientific Scimed, Inc.
InventorsPhilip David Dorgan, Eddy Mateo Flores, Cliodhna Wallace, Rick William Dorn, Joseph Thomas Delaney, JR., Cristian Parisi, Yen-Hao Hsu, Lauren Sfakis Lydecker
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The present disclosure pertains to iodinated poly (amino acid) compounds that comprise residues of alpha amino acids that comprise an alpha carboxyl group, an alpha amino group, and a primary-amine-containing side chain comprising an amino group. The poly(amino acid) compounds comprise amide linkages formed from the alpha carboxyl groups and the amino groups of the primary-amine-containing side chains of the alpha amino acids forming the iodinated poly(amino acid) compound, at least one of the residues of the alpha amino acids in the iodinated poly(amino acid) compound is covalently modified to include one or more iodine atoms, and at least two of the alpha amino acid residues in the iodinated poly(amino acid) compound are not covalently modified. The present disclosure also provides crosslinked radiopaque hydrogels formed from such iodinated poly(amino acid) compounds, methods of treatment using such iodinated poly(amino acid) compounds, and systems containing such iodinated poly(amino acid) compounds.
An iodinated poly(amino acid) compound comprising residues of alpha amino acids that comprise an alpha carboxyl group, an alpha amino group, and a primary-amine-containing side chain comprising an amino group, wherein the poly(amino acid) compound comprises amide linkages formed from the alpha carboxyl groups and the amino groups of the primary-amine-containing side chains of the alpha amino acids forming the iodinated poly(amino acid) compound, wherein at least one of the residues of the alpha amino acids in the iodinated poly(amino acid) compound is covalently modified to include one or more iodine atoms and wherein at least two of the alpha amino acid residues in the iodinated poly(amino acid) compound are not covalently modified.
A system for forming a hydrogel that comprises (a) a first composition comprising an iodinated poly(amino acid) compound that comprises residues of alpha amino acids that comprise an alpha carboxyl group, an alpha amino group, and a primary-amine-containing side chain comprising an amino group, wherein the poly(amino acid) compound comprises amide linkages formed from the alpha carboxyl groups and the amino groups of the primary-amine-containing side chains of the alpha amino acids forming the iodinated poly(amino acid) compound, wherein at least one of the residues of the alpha amino acids in the iodinated poly(amino acid) compound is covalently modified to include one or more iodine atoms and wherein at least two of the alpha amino acid residues in the iodinated poly(amino acid) compound are not covalently modified and (b) a second composition comprising a reactive polymer comprising a plurality of hydrophilic polymer segments and a plurality of reactive moieties, wherein the plurality of reactive moieties are reactive with amino groups of the iodinated poly(amino acid) compound to form covalent crosslinks.
A method of treatment comprising administering to a subject a mixture that comprises (a) an iodinated poly(amino acid) compound that comprises residues of alpha amino acids that comprise an alpha carboxyl group, an alpha amino group, and a primary-amine-containing side chain comprising an amino group, wherein the poly(amino acid) compound comprises amide linkages formed from the alpha carboxyl groups and the amino groups of the primary-amine-containing side chains of the alpha amino acids forming the iodinated poly(amino acid) compound, wherein at least one of the residues of the alpha amino acids in the iodinated poly(amino acid) compound is covalently modified to include one or more iodine atoms and wherein at least two of the alpha amino acid residues in the iodinated poly(amino acid) compound are not covalently modified and (b) a reactive polymer comprising a plurality of hydrophilic polymer segments and a plurality of reactive moieties, wherein the reactive moieties are reactive with amino groups of the iodinated poly(amino acid) compound to form covalent bonds, wherein the mixture is administered under conditions such that the amino groups of the iodinated poly(amino acid) compound and the reactive moieties of the reactive polymer form covalent crosslinks after administration.
Dependencies are inferred from the claim text.