Synthetic antigen receptors for covalent immune recruiters and methods and uses thereof

Abstract

The present description relates to synthetic antigen receptors for use with covalent immune recruiters (CIRs) comprising an donor moiety, a covalent binding group, and a target binding domain (TBD), the synthetic antigen receptor comprising an extracellular acceptor domain and an effector domain, wherein the extracellular acceptor domain is capable of binding to the donor moiety of the CIR. The present description also includes engineered cells comprising the synthetic antigen receptors, methods and uses thereof, for example, for recognition of target cells by immune cells comprising the synthetic antigen receptor functionalized with a CIR.

Dependencies are inferred from the claim text.