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AssigneeXiamen University
InventorsXiaonan WU, Zhiping ZENG, Cheng LEI, Yutong HOU
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Pyrithione derivatives are used in the treatment of colorectal cancer, belonging to the field of biopharmaceutical technology. The affinity of zinc pyrithione (ZPT), copper pyrithione (CPT), and copper pyrithione monomers (CPT monomers) toward the epigenetic modification enzyme HSPBAP1 is verified, wherein the pyrithione derivatives can effectively target the HSPBAP1 protein. Moreover, in vitro migration and invasion assays are also performed on various colorectal cancer cell lines. It is found that ZPT, CPT, and CPT monomers can significantly inhibit the migration and invasion of various colorectal cancer cells in vitro, demonstrating that the pyrithione derivatives have broad-spectrum anti-metastatic capabilities against colorectal cancer.
A method for treating colorectal cancer, comprising administering a medicament comprising a pyrithione derivative to a subject in need thereof, wherein the pyrithione derivative has a structure shown in Formula I, and wherein R in Formula I is selected from Zn+, Cu+ and
A medicament for treating colorectal cancer, wherein the medicament comprises a pyrithione derivative as an active ingredient and further a pharmaceutically acceptable adjuvant;
An epigenetic modification enzyme HSPBAP1-targeted agent comprising a pyrithione derivative, wherein the pyrithione derivative has a structure shown in Formula I, and wherein R in Formula I is selected from Zn+, Cu+ or
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