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US 2026/0242824 A1Published application
Oncolytic viruses to treat brain cancer
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsCamilo Faust Akl, Federico Giovannoni, Francisco J. Quintana
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Abstract
Described herein are compositions comprising engineered herpes simplex viruses (oHSV) comprising a sequence encoding a TRAIL-blocking monoclonal antibody and methods for use thereof in treating brain cancer, e.g., glioblastoma (GBM).
Claims23
An engineered herpes simplex viruses (oHSV) comprising a sequence encoding a tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-blocking monoclonal antibody or antigen-binding fragment thereof.
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Dependencies are inferred from the claim text.