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US 2026/0242734 A1Published application
Method for selecting nk cell donor source
AssigneeEncell Co., Ltd.
InventorsHong Bae JEON, Sang Rae PARK, Ji Hye IM
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Abstract
The present invention relates to a method of selecting a donor source for NK cells with enhanced proliferative capacity, wherein specific single nucleotide polymorphisms (SNPs) of the CISH gene are identified. According to the present invention, in the context of cell therapy comprising NK cells, the method addresses the issue of varying efficacy of NK cells depending on the donor source, thereby enabling the production of NK cells with superior proliferative capacity and consistent quality.
Claims6
A method of selecting a donor source for NK cells comprising:
- (a) identifying a genotype at rs414171, which is a single nucleotide polymorphism site, of a CISH gene in the genome of a donor-derived sample;
- and
- (b) selecting a donor source having an AT genotype or a TT genotype at rs414171 as the donor source for NK cells.
Dependencies are inferred from the claim text.