Stimulatory antigen particles, methods of production, and methods of use thereof
AssigneeGenentech, Inc.
InventorsRichard Carpenedo, Siddarth Chandrasekaran, Manu Thomas Kalathottukaren, Hio Fan Hoi, Elisa Martinez, Alessia Pallaoro, Steven Woodside
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Abstract
The present disclosure provides cell stimulatory particles and methods of using same. Also provided are populations of cells produced using the cell stimulatory particles.
Claims24
A method of generating CD4−CD8+ T cells, comprising:
- contacting a population of CD4+CD8+ cells expressing an antigen receptor with an antigen immobilized to a substrate, wherein the antigen binds to the antigen receptor.
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-23. (canceled)
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A cell stimulatory particle, comprising a particle and a modified antigen immobilized on a surface of the particle, wherein the modified antigen comprises one or more amino acid substitutions from a native antigen, and wherein the modified antigen has greater solubility and/or stability in vitro in comparison to the native antigen.
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Dependencies are inferred from the claim text.