Antibodies and polypeptides comprising variant fc regions
OwnerJoshua PASCOE, Ritu RANDHAWA +1inventors
InventorsJoshua PASCOE, Ritu RANDHAWA, Sonam BHUPTANI
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Abstract
Disclosed herein are antibodies and antigen-binding fragments thereof that bind target antigens (e.g., tumor necrosis factor-like ligand 1A (TL1A)) and polypeptides comprising variant Fc regions.
Claims89
A polypeptide comprising a variant IgG Fc region, wherein the variant IgG Fc region comprises amino acid substitutions at:
- a) position Q311 and/or M428;
- and
- b) position H433 and/or N434;
- relative to a wild-type IgG Fc region, wherein numbering is according to the EU index as in Kabat.
An antibody or antigen-binding fragment thereof that binds tumor necrosis factor-like ligand 1A (TL1A), wherein the antibody or antigen-binding fragment thereof comprises:
- a) a heavy chain variable region (VH) comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 7 and a light chain variable region (VL) comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 8;
- b) a VH comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 13 and a VL comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 14;
- c) a VH comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 7 and a VL comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 18;
- d) a VH comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 7 and a VL comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 20;
- e) a VH comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 23 and a VL comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 20;
- or
- f) a VH comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 28 and a VL comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 20.
An antibody or antigen-binding fragment thereof that binds interleukin 1β (IL1β), wherein the antibody or antigen-binding fragment thereof comprises a heavy chain variable region (VH) comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 49 and a light chain variable region (VL) comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 50.
An antibody or antigen-binding fragment thereof that binds interleukin 13 (IL13), wherein the antibody or antigen-binding fragment thereof comprises:
- a) a heavy chain variable region (VH) comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 59 and a light chain variable region (VL) comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 60;
- b) a VH comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 64 and a VL comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 60;
- or
- c) a VH comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 86 and a VL comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 87.
An antibody or antigen-binding fragment thereof that binds interleukin 15 (IL15), wherein the antibody or antigen-binding fragment thereof comprises a heavy chain variable region (VH) comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 72 and a light chain variable region (VL) comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 73.
An antibody or antigen-binding fragment thereof that binds thymic stromal lymphopoietin (TSLP), wherein the antibody or antigen-binding fragment thereof comprises a heavy chain variable region (VH) comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 84 and a light chain variable region (VL) comprising an amino acid sequence with at least 90% sequence identity to SEQ ID NO:
- 85.
Dependencies are inferred from the claim text.