Back to results
US 2026/0242409 A1Published application
Aminosteroids for the Treatment of a PTP1B Associated Disease
AssigneeDepymed, Inc.
InventorsMichael McLane, Inez Ruiz-White, W. Lee Maloy, Henry R. Wolfe
Life of this patent
Estimating the term…
Abstract
This application is directed to the use of aminosteroid compounds for the selective inhibition of the enzyme PTP1B in a mammal for the treatment of diabetes.
Claims9
A compound or pharmaceutically acceptable salt thereof selected from the group consisting of:
A compound of formula
- or a pharmaceutically acceptable salt thereof,
- wherein:
- R1=—NH(CH2)1-4—NH—R6, H,
- R6=—(CH2)1-4—NH—R7 or —(CH2)0-3—C1-C5 alkyl or —(CH2)0-3—C3-C7cycloalkyl or —(CH2)0-3—C3-C6 heterocycloalkyl or —(CH2)0-3-aromatic or —(CH2)0-3-heteroaromatic or H;
- R7=—(CH2)1-4—NH2 or —(CH2)1-4—NH—(C1-C5 alkyl) or —(CH2)1-4—NH—(C3-C6 heterocycloalkyl) or —(CH2)1-4—NH-aromatic or —(CH2)1-4—NH-heteroaromatic or H;
- R2=—OH or H;
- R3=—OH or NH—R8 or methylsulfone or methyl sulfide or H;
- R8=acetyl, —SO2—CH3 or —C(O)OCH3;
- R4=—OH or H;
- and
7 more elements
A compound of formula
- or a pharmaceutically acceptable salt thereof,
- wherein:
- X2=—OH or H;
- X3=H, —OH, —S(O)2—CH3, —NHC(O)—CH3, —NHC(O)—OCH3, —NHC(O)—SCH3, —NH—SO2CH3 or —SCH3;
- X4=—OH or H;
- and
- X5=H or —CH3.
4 more elements
(canceled)
Dependencies are inferred from the claim text.