Methods and compositions for prevention of anaphylaxis
AssigneesBaylor College of Medicine, The United States of America, as represented by the Secretary, Department of Health and Human
InventorsDavid J. Tweardy, Moses M. Kasembeli, Marvin X. Xu, Josh Milner, Claire Elizabeth Bocchini
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Abstract
Embodiments of the invention include methods of preventing and/or reducing the risk or severity of an allergic reaction in an individual. In some embodiments, particular small molecules are employed for prevention and/or reduction in the risk or severity of anaphylaxis. In at least particular cases, the small molecules are inhibitors of STAT3. In some cases, the small molecule comprises N-(1′,2-dihydroxy-1,2′-binaphthalen-4′-yl)-4-methoxybenzenesulfonamide.
Claims13
A method of treating anaphylaxis or anaphylactic shock in a human individual, comprising administering to the individual having anaphylaxis or anaphylactic shock a therapeutically effective amount of a pharmaceutical composition comprising a Stat3 inhibitor, N-(1′,2-dihydroxy-1,2′-binaphthalen-4′-yl)-4-methoxybenzenesulfonamide, or a salt thereof, and a pharmaceutically acceptable carrier, wherein the therapeutically effect amount is an amount of at most about 100 mg/kg to inhibit Stat3 in the human individual and does not induce toxicity in the human individual.
Dependencies are inferred from the claim text.