Gba1 and gcs dual modulator
AssigneeOno Pharmaceutical Co., Ltd.
InventorsTakashi KONDO, Jun TAKEUCHI, Atsushi KATO
Life of this patent
Estimating the term…
Abstract
A compound represented by formula (I) or a pharmaceutically acceptable salt thereof is provided, which is useful as a pharmaceutical ingredient having GBA1 and GCS dual modulatory activity in the prevention and/or treatment of a disease associated with GBA1 and/or GCS, in which all symbols represent the same meaning as the symbols described in the specification. A drug is also provided, which containing, as an active ingredient, a compound having GBA1 and GCS dual modulatory activity in prevention and/or treatment of a disease associated with GBA1 and/or GCS.
Claims24
A compound of formula (I) or a pharmaceutically acceptable salt thereof:
- wherein
- L1 represents (1) a C4-7 alkylene, (2) a C4-7 alkenylene, or (3) a C4-7 alkynylene,
- L1 may be substituted with one to five RL1s,
- RL1 represents (1) a halogen atom, (2) a C1-6 alkyl group, (3) a C2-6 alkenyl group, (4) a C2-6 alkynyl group, (5) a C1-6 alkoxy group, (6) a C1-6 haloalkyl group, (7) a C2-6 haloalkenyl group, (8) a C2-6 haloalkynyl group, (9) a C1-6 haloalkoxy group, or (10) a hydroxyl group,
- a plurality of RL1s may be the same or different,
- L2 represents (1) a C1-3 alkylene, (2) a C2-3 alkenylene or (3) a C2-3 alkynylene,
- L2 may be substituted with one to four RL2s,
- RL2 represents (1) a halogen atom, (2) a C1-6 alkyl group, (3) a C2-6 alkenyl group, (4) a C2-6 alkynyl group, (5) a C1-6 alkoxy group, (6) a C1-6 haloalkyl group, (7) a C2-6 haloalkenyl group, (8) a C2-6 haloalkynyl group, (9) a C1-6 haloalkoxy group, or (10) a hydroxyl group,
- a plurality of RL2s may be the same or different,
- X represents (1) a bond, (2) —O—, (3) —S—, (4) —SO—, or (5) —SO2—,
- Ring1 represents (1) a benzene ring (2) a naphthalene ring or (3) a 5- to 10-membered heterocyclyl,
- R1 represents (1) a halogen atom, (2) a C1-6 alkyl group, (3) a C2-6 alkenyl group, (4) a C2-6 alkynyl group, (5) a C1-6 alkoxy group, (6) a C1-6 haloalkyl group, (7) a C2-6 haloalkenyl group, (8) a C2-6 haloalkynyl group, (9) a C1-6 haloalkoxy group, (10) a C5-7 carbocyclyl, (11) a 5- to 7-membered heterocyclyl, (12) —O—(C5-7 carbocyclyl), or (13) —O-(5- to 7-membered heterocyclyl),
- a plurality of R1s may be the same or different,
- the groups (2) to (13) in R1 may be substituted with one to five R1-1s,
- R1-1 represents (1) a halogen atom, (2) a C1-6 alkyl group, (3) a C2-6 alkenyl group, (4) a C2-6 alkynyl group, (5) a C1-6 alkoxy group, (6) a C1-6 haloalkyl group, (7) a C2-6 haloalkenyl group, (8) a C2-6 haloalkynyl group, (9) a C1-6 haloalkoxy group, (10) a C1-6 alkyl sulfonyl group, (11) a cyano group, or (12) a phenyl group,
- a plurality of R1-1s may be the same or different,
- the symbol:
- represents that a substituent is bonded to the α-configuration, β-configuration or a mixture of α- and β-configurations at an appropriate ratio, and
- n represents an integer of 0 to 5.
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Dependencies are inferred from the claim text.