BICYCLIC HETEROCYCLIC AMIDE INHIBITORS OF NAv1.8 FOR THE TREATMENT OF PAIN

A compound of Formula (I):

• wherein:
• R1, independently in each instance, is selected from hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C1-C6 haloalkyl, halo-C1-C6 alkoxy, C3-C6-cycloalkyl, and C3-C6-cycloalkylC1-C3-alkyl;
• or wherein two R1 are attached on adjacent ring carbons in
• and together with the adjacent carbons to which they are attached form
• where * indicate the shared carbons in
• A is C6-C10 aryl substituted with R3 and optionally substituted with (R3a)q;
• 5- to 10-membered heteroaryl substituted with R3 and optionally substituted with (R3a)q;
• or
• optionally substituted with (R3a)q1;
• W1 is —N═, —C(H)═, —C(halogen)=, —C(C1-C6 alkyl)=, or —C(cyclopropyl)=;
• W2 and W3 are each —C—, the dashed bond between W2 and W3 is a double bond, and
• is a partially unsaturated 5 to 7-membered carbocyclic ring, a benzo ring, a partially unsaturated 5 to 7-membered heterocyclic ring, or a 5 or 6-membered heteroaromatic ring;
• or
• one of W2 and W3 is —C— and the other is —N—, the dashed bond between W2 and W3 is a single bond, and
• is a 5 or 6-membered heterocyclic ring optionally comprising an additional N and where the remaining ring atoms are C;
• R2, independently in each instance, is hydrogen, halogen, or C1-C6 alkyl;
• or
• two R2 are attached on adjacent carbons and together with the carbons to which they are attached form a 4- to 7-membered carbocyclic ring and the remaining R2, independently in each instance, is hydrogen, halogen, or C1-C6 alkyl;
• or
• two R2 are attached on the same carbon and together with the carbon to which they are attached form a 4- to 7-membered carbocyclic ring and the remaining R2, independently in each instance, is hydrogen, halogen, or C1-C6alkyl;
• R3 is hydrogen, —C(O)NH2, —NH2, —S(O)2NHR, —S(O)2C1-C6-alkyl, or
• wherein R is hydrogen, C1-C3 alkyl or C3-C5 cycloalkyl;
• R3a, independently in each instance, is hydrogen, halogen, C1-C3 alkyl, or C3-C6 cycloalkyl;
• m is 0, 1, 2, or 3;
• n is 0, 1, 2, 3, or 4;
• p is 0, 1, 2, 3, 4, 5, or 6;
• q1 is 0, 1, or 2;
• and
• q is 0, 1, 2, or 3;
• or a pharmaceutically acceptable salt thereof and/or an isomer thereof.