Nasal administration
AssigneeOptiNose AS
InventorsPer Gisle DJUPESLAND, Ramy A. MAHMOUD, John MESSINA
Life of this patent
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Abstract
A method of delivering a substance, such as one or more of a triptan, a nasal steroid or carbon dioxide gas, to the nasal cavity of a subject, in particular for the treatment of headaches, for example, migraine, or rhinosinusitis, for example, chronic rhinosinusitis, optionally with polyps, the method comprising the steps of fitting a nosepiece to one nostril of the subject, delivering the substance through the nosepiece to the posterior region of the nasal cavity of the subject.
Claims80
A method of therapeutically treating a patient,
- comprising:
- administering, in a first step, a therapeutic agent;
- and
- delivering, in a second step, to a location at an interior of a nasal passage of the patient a therapeutic amount of at least one of carbon dioxide or a pH adjusting material, wherein the first step is performed at least one of before, after, before and after, and at the same time as the second step.
A method for increasing a therapeutic effect of a pharmaceutical agent delivered to a patient, comprising:
- delivering a fluid flow to a nasal passage of the patient to deliver about 5% to about 6% vol/vol carbon dioxide to a posterior region of the nasal passage;
- and
- administering a dose of the pharmaceutical agent to the patient.
A method of treating a patient, comprising delivering a concentration of about 5% to about 6% vol/vol carbon dioxide to a nostril of the patient to lower a pH of an upper posterior region of the nasal passage by at least about 0.1 pH units to provide a therapeutic or pharmacokinetic effect.
A method of treating migraine in a patient,
- comprising:
- intranasally administering, in a first step, a triptan;
- and
- delivering, in a second step, to a location at an interior of a nasal passage of the patient a therapeutic amount of at least one of carbon dioxide or a pH adjusting material, wherein the first step is performed at least one of before, after, before and after, and at the same time as the second step;
- wherein less than 2% of treated patients exhibit atypical triptan sensations consisting of tingling, warm/hot sensation, burning sensation, feeling of heaviness, pressure, feeling of tightness, including tightness in the head, numbness and feeling strange.
Dependencies are inferred from the claim text.