Interface and method for the preparation of material for transfer into a mass spectrometer

An interface for preparation of material, in particular biological, for transfer thereof into a mass spectrometer, where the material is in aerosol form, the interface comprising:

• a Ventu An interface for preparation of material, in particular biological, for transfer ri system with two inlets and one outlet,
• a heater,
• a corona discharge needle for ionizing the material in aerosol form, wherein the interface further comprises:
• a nebulizer for generating a mist,
• a transfer tube connected to the outlet of the Venturi system, and in that:
• the heater is configured for heating the transfer tube,
• the corona discharge needle is located at the outlet of the transfer tube, and
• the Venturi system is configured for receiving the material in aerosol form by one of its inlets and is connected to the nebulizer by the other of its inlets leading to the solvation of the material in aerosol form by the mist in the Venturi system.

A method for material preparation, in particular biological, for transfer thereof into a mass spectrometer comprising:

• routing the material in aerosol form towards a Venturi system, wherein the method further comprises:
• injecting a mist comprising solvent droplets into the Venturi system,
• solvating, in the Venturi system, the material in aerosol form into the solvent droplets from the mist,
• heating the mixture of the solvated material in the solvent droplets from the mist by a heater located around a transfer tube connected to an outlet of the Venturi system leading to the desolvation of the material, and
• ionizing the material by a corona discharge delivered at the outlet of the transfer tube.