Co-cultured cardiomyocytes on chip (coco chip) with piezoelectric sensing

Abstract

A cell-culture device for measuring forces exerted by cells includes a housing with one or more cell culture sections. Each cell culture section includes one or more compartments for seeding one or more cell types, and each compartment has a bottom surface that is coated with a layer of piezoelectric polydimethylsiloxane (PE-PDMS). Forces exerted by cells can be measured by seeding cells in the cell-culture device and detecting an electrical signal generated by the layer of PE-PDMS. The electrical signal is indicative of a mechanical movement converted to the electrical signal proportional to contractile force exerted from the cells. The electrical signal can be converted to an output of a contractile force measurement.

Dependencies are inferred from the claim text.