Bi-specific extracellular matrix binding peptides and methods of use thereof
AssigneeUniversity of Tartu
InventorsTambet TEESALU, Prakash Lingasamy
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Abstract
Disclosed are compositions, compounds, and methods relating to peptides that can target and home to cancer, tumors, and extracellular matrix. This is based on the discovery of peptides that can specifically bind to fibronectin extra domain B (FN-EDB), tenascin-C C domain (TNC-C), or both.
Claims23
1-4. (canceled)
An isolated peptide comprising an amino acid sequence comprising TSKQNSR (SEQ ID NO:3) or a variant of TSKQNSR (SEQ ID NO:3) with one, two, three, four, five, or six amino acid substitutions, wherein position 7 remains arginine and/or position 6 remains serine.
An isolated peptide comprising an amino acid sequence comprising AGRGRLVR (SEQ ID NO:4) or a variant of AGRGRLVR (SEQ ID NO:4) with one, two, three, four, five, six, or seven amino acid substitutions, wherein position 3 remains arginine, optionally (i) wherein position 6 remains leucine and/or position eight remains arginine, or (ii) wherein position 6 remains leucine, position eight remains arginine, and position 5 remains arginine.
An isolated peptide comprising a first amino acid sequence comprising TSKQNSR (SEQ ID NO:3) or a variant of TSKQNSR (SEQ ID NO:3) with one, two, three, four, five, or six amino acid substitutions, wherein position 7 remains arginine and/or position 6 remains serine, and a second amino acid sequence comprising AGRGRLVR (SEQ ID NO:4) or a variant of AGRGRLVR (SEQ ID NO:4) with one, two, three, four, five, six, or seven amino acid substitutions, wherein position 3 remains arginine.
Dependencies are inferred from the claim text.