Isotopologues of aminoheteroaryl kinase inhibitors and uses thereof
AssigneeAllorion Therapeutics Inc
InventorsDai CHENG, Xiaohang YIN, Zeqiang XIE
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Abstract
Provided are isotopologues of aminoheteroaryl compounds for inhibiting cyclin-dependent kinases, processes for the preparation of the compounds, pharmaceutical compositions comprising the compounds, and methods of treatment of diseases and disorders using the compounds or pharmaceutical compositions.
Claims15
1-31:
- (canceled)
A method of producing 4-amino-N-(methyl-d3)benzene-2,3,5,6-d4-sulfonamide, the method comprising hydrolyzing N-(4-(N-(methyl-d3)sulfamoyl)phenyl-2,3,5,6-d4)acetamide.
A method of producing 2,4-dichloro-5-(trifluoromethyl)pyrimidine-6-d, the method comprising reacting 5-(trifluoromethyl)pyrimidine-6-d-2,4-diol with phosphoryl chloride.
A compound selected from:
Dependencies are inferred from the claim text.