Reinforcement wires for tenecteplase drug-coated balloon

A drug-coated balloon for intracranial atherosclerosis, the drug-coated balloon configured to be inserted through a portion of a main intracranial artery with plaque creating a progressive stenosis, the drug-coated balloon comprising:

• a body portion having a distal end, a proximal end opposite the distal end, and a sidewall extending between the distal end and the proximal end, the body portion movable between a deflated position and an inflated position;
• and
• a plurality of wires supported within the body portion, the wires defining concentric rings and longitudinal wires that extend longitudinally along the longitudinal axis at least partially between the distal end and the proximal end, each wire restricting a portion of the balloon from expanding when the body portion moves to the inflated position, the portion of the balloon that is restricted from expanding forms recessed circumferential portions and recessed longitudinal portions in the sidewall of the balloon,
• wherein the recessed circumferential portions and the recessed longitudinal portions are configured to reduce an amount of plaque that moves from the main intracranial artery to perforator arteries.