Pet/mri contrast agents for in vivo quantification of extracellular acidification

Abstract

The disclosure provided a composition for imaging, comprising a compound of the general formula (I), wherein X is 18F, or 19F; Y is independently selected from —(CH2)n—COOH or —(CH2)n—COO(CH2)mY1, wherein n is 1, 2 or 3, m is 0, 1 or 2, and Y1 is C1 to C5 linear or branched alkyl; and Z is —Z1—NHSO2—Z2, Z1 is linear or branched C1 to C5 alkyl or alkenyl, and Z2 is substituted or unsubstituted alkyl, cyclyl or heterocyclyl; or a salt thereof; a Lanthanide compound; and optionally pharmaceutically acceptable excipients, wherein a Lanthanide complex is formed between the compound of formula (I) or salt thereof and the Lanthanide compound. In addition, a method of synthesis a composition for imaging, methods of using the composition for imaging, a method of using the composition evaluation of pH and/or perfusion a compound, and a method of synthesis a compound are provided.

Dependencies are inferred from the claim text.