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US 2026/0232791 A1Published application
Pharmaceutical compositions for delivery of herpes simplex virus glycoprotein c, glycoprotein d, and glycoprotein e antigens and related methods
AssigneeBioNTech SE
InventorsAlptekin Güler, Ricardo Sanchez Velazquez, Julia Uebele, Annette Vogel, Christina Pfafenrot, Anna Luise Ernst, Stephanie Hein, Sabrina Hinz, Sarah Catharina Dany
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Abstract
The present disclosure provides pharmaceutical compositions for delivery of HSV antigens (e.g., an HSV vaccine) and related technologies (e.g., components thereof and/or methods relating thereto).
Claims55
1. A combination comprising:
- a polyribonucleotide encoding an HSV glycoprotein C (gC) antigen or antigenic fragment thereof, a polyribonucleotide encoding an HSV glycoprotein D (gD) antigen or antigenic fragment thereof, and a polyribonucleotide encoding an HSV glycoprotein E (gE) antigen or antigenic fragment thereof, wherein:
- (i) the polyribonucleotide encoding HSV gC antigen or antigenic fragment thereof comprises a ribonucleic acid sequence with at least 90% sequence identity to SEQ ID NO:
- 336;
- (ii) the polyribonucleotide encoding HSV gD antigen or antigenic fragment thereof comprises a ribonucleic acid sequence with at least 90% sequence identity to SEQ ID NO:
- 340;
- (iii) the polyribonucleotide encoding HSV gE antigen or antigenic fragment thereof comprises a ribonucleic acid sequence with at least 90% sequence identity to SEQ ID NO:
- 283;
- or
- (iv) any combination thereof.
6 more elements
A combination comprising:
- a polyribonucleotide encoding a polypeptide comprising
- (i) an amino acid sequence with at least 90% identity to SEQ ID NO:
- 213 and
- (ii) an amino acid sequence with at least 90% identity to SEQ ID NO:
- 260;
- a polyribonucleotide encoding a polypeptide comprising
- (i) an amino acid sequence with at least 90% identity to SEQ ID NO:
- 29 and
- (ii) an amino acid sequence with at least 90% identity to SEQ ID NO:
- 2;
- and
- a polyribonucleotide encoding a polypeptide comprising an
- (i) an amino acid sequence with at least 90% identity to SEQ ID NO:
- 30 and
- (ii) an amino acid sequence with at least 90% identity to SEQ ID NO:
- 3.
13 more elements
Dependencies are inferred from the claim text.