Factor b inhibitors and uses thereof
AssigneeThe Trustees of the University of Pennsylvania
InventorsWenchao Song, Hangsoo Kim, Takashi Miwa, Damodara Rao Gullipalli
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Abstract
This invention relates to factor B inhibitors or nucleic acid molecules encoding thereof and selective inhibition of the alternative pathway (AP) of the complement system using said factor B inhibitors or nucleic acid molecules encoding thereof or compositions thereof. The invention also provides methods of treating an AP complement-mediated disease or AP complement-mediated disorder in a subject by administering a therapeutically effective amount of the factor B inhibitor or nucleic acid molecules encoding thereof or composition thereof.
Claims20
1-15. (canceled)
A method of preventing or treating an alternative pathway (AP)-mediated disease or disorder in a subject in need thereof, wherein the method comprises administering a therapeutically effective amount of at least one factor B inhibitor or a composition thereof to the subject.
A method of reducing the activity of an alternative pathway of a complement system of a subject, wherein the method comprises administering a therapeutically effective amount of at least one factor B inhibitor or a composition thereof to the subject.
24-27. (canceled)
A method of administering a therapeutically effective amount of at least one factor B inhibitor or a composition thereof to the subject, wherein the subject has a complement-mediated disease or disorder.
Dependencies are inferred from the claim text.