Methods for identifying disseminated cancer cells in breast cancer patients
AssigneeH. Lee Moffitt Cancer Center and Research Institute, Inc.
InventorsBrian CZERNIECKI, Ganesan RAMAMOORTHI
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Abstract
Disclosed are methods for the detection and isolation of disseminated cancer cells and the used of tumor antigen pulsed type 1 dendritic cell vaccine for the treatment and prevention of metastasis and abscopal tumors.
Claims21
A method of reducing cancer cell dissemination and/or metastasis in a subject with a cancer comprising administering to the subject tumor antigen-pulsed Type 1 conventional dendritic cells (cDC1).
A method of reducing cancer cell dissemination and/or metastasis in a subject with a cancer comprising:
- (i) obtaining CD4Th1 T cells;
- (ii) contacting the CD4 T cells with tumor antigen pulsed Type 1 conventional dendritic cells thereby creating DC1 primed CD4 T cells;
- and
- (iii) administering to the subject the DC1 primed CD4 T cells.
A method of treating cancer metastasis in a subject, wherein the method comprises;
- (i) obtaining a tissue sample from the subject;
- (ii) performing imaging or a proteomic assay of the tissue sample to detect the presence of DCC in the subject;
- and
- (iii) if the presence of DCC in the subject is seen, then treating the subject with a a treatment selected from hormone therapy, immunotherapy, targeted therapy, chemotherapy, or combinations thereof.
Dependencies are inferred from the claim text.