Methods of supermere detection and quantification

Abstract

Described herein is the novel discovery that supermeres comprise a high negative charge due to the presence of RNA-DNA hybrid molecules on their surface. The unique negative charge of supermeres, along with their specific protein content, can be used for detection and diagnostic applications. Also described herein are methods for detecting and quantifying supermeres in a sample that comprise the use of capture probes and charge-sensitive ion-selective sensors that are sensitive to the high negative charge of supermeres. Also described herein are methods for detecting cancer in a subject that comprise detecting and quantifying a concentration of one or more supermere-related cancer biomarkers.

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