Etv1 monoclonal antibodies
AssigneeThe Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
InventorsShyh-Han TAN, Albert DOBI, Shiv K. SRIVASTAVA
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Abstract
Disclosed are monoclonal antibodies, antigen-binding fragments thereof, and other binding molecules derived therefrom that bind to ETV1 (ETS Variant Transcription Factor 1). Also disclosed are epitopes of ETV1 that can be used to make antibodies that bind to ETV1. In addition, methods of using these antibodies, or antigen-binding fragments thereof, are disclosed, including methods of detecting ETV1 in a sample, and methods of diagnosing and treating cancer.
Claims30
A monoclonal antibody, or an antigen-binding fragment thereof, that binds to an epitope of ETV1 (ETS Variant Transcription Factor 1), comprising a heavy chain variable domain and a light chain variable domain, wherein:
- a) the heavy chain variable domain comprises a complementarity determining region 1 (CDR1) comprising the amino acid sequence of SEQ ID NO:
- 3, a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 4, and a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 5, and wherein the light chain variable domain comprises a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 6, a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 7, and a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 8;
- or
- b) the heavy chain variable domain comprises a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 9, a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 10, and a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 11, and wherein the light chain variable domain comprises a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 12, a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 13, and a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 14.
An immunogenic composition comprising an epitope of ETV1, wherein the epitope of ETV1 comprises the amino acid sequence of SEQ ID NO:
- 15 or SEQ ID NO:
- 16.
Dependencies are inferred from the claim text.