Micro-balance biosensors to detect whole viruses

Abstract

The present disclosure describes methods of detecting viral biomolecules such as viruses through frequency response. A method of detecting a virus includes exposing a sensor surface to a fluid sample containing a suspected virus. The sensor surface can be a surface of a resonator having a clean resonant frequency from about 1 MHz to about 1 GHz. The surface can be modified with molecular recognition groups selective for binding to the viral biomolecule. A resonant frequency of the resonator can be measured after exposing the sensor surface to the fluid sample. The measured resonant frequency can be compared with a clean resonant frequency indicating the presence of the viral biomolecule bound to the molecular recognition groups and then outputted as a detection signal.

Dependencies are inferred from the claim text.