Preparation method and application of a chiral amine compound and its salts
AssigneeTongli Biomedical Co., Ltd.
InventorsMingxin QIAN, Donald C. HOU
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Abstract
The present application relates to a preparation method and application of a chiral amine compound and its salt. The method comprises the following steps: (1) causing compound 1 to react in the presence of imine reductase, NADP, glucose dehydrogenase, glucose, a solvent, and a co-solvent to obtain compound 2 and/or compound 2-A; (2) converting the compound 2 and/or compound 2-A into the chiral amine compound TL-010-2 and its salts.
Claims20
A method for preparing a chiral amine compound and its salt comprising the following steps:
- (1) causing compound 1 to react in the presence of imine reductase, NADP, glucose dehydrogenase, glucose, a solvent, and a co-solvent to obtain compound 2 and/or compound 2-A;
- (2) converting the compound 2 and/or compound 2-A into the chiral amine compound (1R)-(−)-1-aminomethyl-1,2,3,4-tetrahydroisoquinoline (TL-010-2);
- wherein, the structural formula of the compound 1 is:
- the structural formula of the compound 2 is:
- the structural formula of the compound 2-A is:
- and the structural formula of the TL-010-2 is
A salt of a chiral amine having a structure of Formula
A method for preparing (R)-praziquantel comprising the following steps:
- 1) causing compound 1 to react in the presence of imine reductase, NADP, glucose dehydrogenase, glucose, a solvent, and a co-solvent to obtain compound 2 and/or compound 2-A;
- 2) converting the compound 2 and/or compound 2-A into a chiral amine compound TL-010-2;
- or further converting the chiral amine compound TL-010-2 into a salt of TL-010-2;
- 3) Preparing the (R)-praziquantel using the chiral amine compound TL-010-2 or the salt of TL-010-2 thereof as the starting material;
- wherein, the structural formula of the compound 1 is:
- the structural formula of the compound 2 is:
- the structural formula of the compound 2-A is:
- the structural formula of the chiral amine compound TL-010-2 is
- the structural formula of the salts of TL-010-2 are:
Dependencies are inferred from the claim text.