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AssigneeBoehringer Ingelheim International GmbH
InventorsThomas WUCHERPFENNIG, Maike KUSCHEL, Juergen FITSCHEN, Michael SCHLUETER
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The present disclosure is directed to a foam destroying device for destroying foam (170) and/or controlling the foam height HF in a reactor (100) in which a foam-generating method is carried out, wherein a flexible tube (10, 180) attached to a rigid fluid line (185) only at one end (20, 181) which can come into contact with the liquid level (155) in a reactor (100) is caused to move chaotically by compressed fluid flowing there through, whereby the chaotic movement of the tube (10, 180) and the compressed fluid flowing out of the tube (10, 180) destroys or controls the foam (170) formed. A process for destroying foam (170) and/or controlling the foam height HF in a reactor (100) in which a foam-generating method is performed is also provided. Antifoam agents or mechanically-electronically operated or electronically driven components, such as motors, for destroying and suppressing foam are no longer required. The present disclosure is further directed to methods for culturing prokaryotic or eukaryotic cells in liquid cell culture in a bioreactor equipped with a respective foam destroying device and respective methods for producing a recombinant protein.
A foam destruction device for destroying foam (170, 270) and/or controlling the foam height Hp in a reactor (100, 200) in which a foam-generating method is carried out, comprising:
A process for destroying foam (170, 270) and/or controlling the foam height HF in a reactor (100, 200) in which a foam-generating method is to be carried out, comprising the steps of:
Dependencies are inferred from the claim text.