US 2026/0226134 A1 · ANTI-MAGE-A4 T CELL RECEPTORS · patentgrep

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Abstract

The present invention relates to T cell receptors (TCRs) and, in particular, TCRs specific for peptides derived from Melanoma-associated antigen 4 (MAGE-A4). The present invention also relates to antigen-binding portions of said TCRs, compositions comprising said TCRs or portions, fusion proteins comprising said TCRs or portions, nucleic acids and vectors encoding said TCRs or portions, cells comprising said TCRs or portions, and methods of treatment involving said TCRs or portions.

Claims37

Dependent claims

A T cell receptor (TCR), or an antigen-binding portion thereof, capable of binding specifically to a peptide according to SEQ ID NO:

122 presented in the context of an MHC class I molecule, comprising:
a TCR-alpha (TCR-a) variable region, or portion thereof, and a TCR-beta (TCR-b) variable region, or portion thereof, wherein
the TCR-a variable region, or portion thereof, comprises a complementarity determining region 3 alpha (CDR3a) comprising SEQ ID NO:
49 or SEQ ID NO:
53, wherein the CDR3a does not comprise SEQ ID NO:
7;
and/or the TCR-b variable region, or portion thereof, comprises a complementarity determining region 3 beta (CDR3b) comprising SEQ ID NO:
62 or SEQ ID NO:
64, wherein the CDR3b does not comprise SEQ ID NO:
14.

7 more elements

A TCR, or an antigen-binding portion thereof, capable of binding specifically to a peptide according to SEQ ID NO:

122 presented in the context of an MHC class I molecule, comprising:
a TCR-a variable region, or portion thereof, and a TCR-b variable region, or portion thereof, wherein
the TCR-a variable region, or portion thereof, comprises a CDR3a and the TCR-b variable region, or portion thereof, comprises a CDR3b;
the CDR3a comprises any one of the CDR3a sequences recited in Table 1;
the CDR3b comprises any one of the CDR3b sequences recited in Table 2;
and
the CDR3a and CDR3b are associated with the same TCR ID listed in Tables 1 and 2.

4 more elements

A TCR, or an antigen-binding portion thereof, capable of binding specifically to a peptide according to SEQ ID NO:

122 presented in the context of an MHC class I molecule, comprising:
a TCR-a variable region, or portion thereof, and a TCR-b variable region, or portion thereof, wherein
the TCR-a variable region, or portion thereof, comprises a CDR1a, a CDR2a, and a CDR3a and the TCR-b variable region, or portion thereof, comprises a CDR1b, a CDR2b, and a CDR3b;
and
the CDR1a comprises any one of the CDR1a sequences recited in Table 1;
the CDR2a comprises any one of the CDR2a sequences recited in Table 1;
the CDR3a comprises any one of the CDR3a sequences recited in Table 1;
the CDR1b comprises any one of the CDR1b sequences recited in Table 2;
the CDR2b comprises any one of the CDR2b sequences recited in Table 2;
the CDR3b comprises any one of the CDR3b sequences recited in Table 2;
and
the CDR1a, CDR2a, CDR3a, CDR1b, CDR2b, and CDR3b are all associated with the same TCR ID listed in Tables 1 and 2 (i.e. derived from the same clone).

9 more elements

A TCR, or an antigen-binding portion thereof, capable of binding specifically to a peptide according to SEQ ID NO:

122 presented in the context of an MHC class I molecule, comprising:
a TCR-a variable region, or portion thereof, and a TCR-b variable region, or portion thereof, wherein
(1) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
7 or SEQ ID NO:
26 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(2) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
7 or SEQ ID NO:
26 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(3) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
7 or SEQ ID NO:
26 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(4) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
7 or SEQ ID NO:
26 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(5) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
27 or SEQ ID NO:
28 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(6) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
29 or SEQ ID NO:
30 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(7) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
31 or SEQ ID NO:
32 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(8) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
33 or SEQ ID NO:
34 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(9) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
29 or SEQ ID NO:
30 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(10) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
31 or SEQ ID NO:
32 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(11) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
29 or SEQ ID NO:
30 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(12) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
31 or SEQ ID NO:
32 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(13) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
7 or SEQ ID NO:
26 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
58 or SEQ ID NO:
59;
or
(14) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
7 or SEQ ID NO:
26 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
58 or SEQ ID NO:
59;
or
(15) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
7 or SEQ ID NO:
26 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
58 or SEQ ID NO:
59;
or
(16) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
7 or SEQ ID NO:
26 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
58 or SEQ ID NO:
59;
or
(17) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
27 or SEQ ID NO:
28 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
58 or SEQ ID NO:
59;
or
(18) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
7 or SEQ ID NO:
26 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
58 or SEQ ID NO:
59;
or
(19) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
31 or SEQ ID NO:
32 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
58 or SEQ ID NO:
59;
or
(20) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
35 or SEQ ID NO:
36 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(21) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
37 or SEQ ID NO:
38 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(22) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
39 or SEQ ID NO:
40 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(23) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
41 or SEQ ID NO:
42 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(24) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
35 or SEQ ID NO:
36 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
58 or SEQ ID NO:
59;
or
(25) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
37 or SEQ ID NO:
38 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
58 or SEQ ID NO:
59;
or
(26) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
39 or SEQ ID NO:
40 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
58 or SEQ ID NO:
59;
or
(27) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
41 or SEQ ID NO:
42 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
58 or SEQ ID NO:
59;
or
(28) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
43 or SEQ ID NO:
44 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
58 or SEQ ID NO:
59;
or
(29) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
29 or SEQ ID NO:
30 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(30) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
29 or SEQ ID NO:
30 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(31) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
31 or SEQ ID NO:
32 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(32) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
31 or SEQ ID NO:
32 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(33) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
31 or SEQ ID NO:
32 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(34) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
7 or SEQ ID NO:
26 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(35) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
31 or SEQ ID NO:
32 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(36) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
31 or SEQ ID NO:
32 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(37) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
31 or SEQ ID NO:
32 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(38) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
31 or SEQ ID NO:
32 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(39) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
31 or SEQ ID NO:
32 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(40) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
29 or SEQ ID NO:
30 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(41) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
29 or SEQ ID NO:
30 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(42) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
29 or SEQ ID NO:
30 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(43) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
45 or SEQ ID NO:
46 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(44) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
47 or SEQ ID NO:
48 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(45) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
45 or SEQ ID NO:
46 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
58 or SEQ ID NO:
59;
or
(46) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
45 or SEQ ID NO:
46 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(47) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
47 or SEQ ID NO:
48 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(48) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
31 or SEQ ID NO:
32 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(49) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
31 or SEQ ID NO:
32 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57;
or
(50) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
31 or SEQ ID NO:
32 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
60 or SEQ ID NO:
61;
or
(51) the TCRa variable region, or portion thereof, comprises a CDR3a comprising or according to SEQ ID NO:
140 or SEQ ID NO:
141 and the TCRb variable region, or portion thereof, comprises a CDR3b comprising or according SEQ ID NO:
14 or SEQ ID NO:
57.

304 more elements

A TCR, or an antigen-binding portion thereof, capable of binding specifically to a peptide according to SEQ ID NO:

122 presented in the context of an MHC class I molecule, comprising:
a TCR-a variable region, or portion thereof, and a TCR-b variable region, or portion thereof, wherein
(1) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 18, and 7/26 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(2) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 19, 7/26 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(3) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 20, 7/26 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(4) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 21, 7/26 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(5) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 27/28 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(6) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
15, 6, 29/30 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(7) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 31/32 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(8) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
15, 6, 33/34 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(9) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 29/30 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(10) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
15, 6, 31/32 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(11) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
15, 6, 29/30 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(12) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 31/32 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(13) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 18, 7/26 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 58/59 respectively;
or
(14) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 19, 7/26 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 58/59 respectively;
or
(15) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 20, 7/26 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 58/59 respectively;
or
(16) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 21, 7/26 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 58/59 respectively;
or
(17) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 27/28 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 58/59 respectively;
or
(18) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 7/26 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 58/59 respectively;
or
(19) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 31/32 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 58/59 respectively;
or
(20) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 35/36 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(21) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 37/38 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(22) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 39/40 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(23) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 41/42 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(24) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 35/36 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 58/59 respectively;
or
(25) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 37/38 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 58/59 respectively;
or
(26) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 39/40 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 58/59 respectively;
or
(27) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 41/42 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 58/59 respectively;
or
(28) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 43/44 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 58/59 respectively;
or
(29) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
15, 22, 29/30 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(30) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
15, 23, 29/30 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(31) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
15, 22, 31/32 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(32) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
15, 23, 31/32 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(33) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
15, 6, 31/32 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(34) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
15, 6, 7/26 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(35) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
16, 22, 31/32 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(36) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
17, 23, 31/32 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(37) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
17, 6, 31/32 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(38) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 23, 31/32 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(39) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 22, 31/32 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(40) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 29/30 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(41) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 23, 29/30 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(42) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 22, 29/30 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(43) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 45/46 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(44) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 19, 47/48 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(45) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 19, 45/46 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 58/59 respectively;
or
(46) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 19, 45/46 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(47) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 19, 47/48 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(48) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 19, 31/32 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(49) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 19, 31/32 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 56, 14/57 respectively;
or
(50) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 31/32 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 60/61 respectively;
or
(51) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 6, 140/141 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively;
or
(52) the TCRa variable region, or portion thereof, comprises a CDR1a, CDR2a, and CDR3a comprising or according to SEQ ID NOs:
5, 22, 140/141 respectively and the TCRb variable region, or portion thereof, comprises a CDR1b, CDR2b, and CDR3b comprising or according to SEQ ID NOs:
12, 13, 14/57 respectively.

206 more elements

A TCR, or an antigen-binding portion thereof, capable of binding specifically to a peptide according to SEQ ID NO:

122 presented in the context of an MHC class I molecule, comprising:
a TCR-a variable region, or portion thereof, and a TCR-b variable region, or portion thereof, wherein
(1) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
82 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(2) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
83 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(3) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
84 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(4) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
85 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(5) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
86 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(6) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
87 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(7) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
88 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
117;
or
(8) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
89 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
117;
or
(9) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
90 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
117;
or
(10) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
91 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
117;
or
(11) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
92 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
117;
or
(12) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
93 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(13) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
82 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
118;
or
(14) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
83 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
118;
or
(15) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
84 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
118;
or
(16) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
85 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
118;
or
(17) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
86 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
118;
or
(18) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
3 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
118;
or
(19) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
93 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
118;
or
(20) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
94 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(21) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
95 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(22) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
96 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(23) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
97 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(24) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
94 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
118;
or
(25) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
95 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
118;
or
(26) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
96 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
118;
or
(27) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
97 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
118;
or
(28) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
98 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
118;
or
(29) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
99 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(30) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
100 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(31) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
101 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(32) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
102 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(33) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
103 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(34) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
104 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(35) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
105 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(36) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
106 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(37) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
107 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
119;
or
(38) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
108 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(39) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
109 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(40) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
110 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(41) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
111 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(42) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
112 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(43) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
113 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(44) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
114 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(45) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
115 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
118;
or
(46) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
115 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(47) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
114 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(48) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
116 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(49) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
116 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
120;
or
(50) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
93 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
121;
or
(51) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
142 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(52) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
143 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
10;
or
(53) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
142 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
119;
or
(54) the TCRa variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
98 and the TCRb variable region comprises a sequence that is at least 70%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO:
144.

214 more elements

Dependencies are inferred from the claim text.

Facts

Application: 19/153,255Filed 1 Feb 2024
Priority: EP 23154990.83 Feb 2023
Published: 6 Aug 2026
Term ends: Not estimatedThe source records don’t support an estimate.

Classification18 codes

C07K 14/7051
Immunoglobulin superfamily: t-cell receptor -CD3 complex
A61K 35/17
Blood; Artificial blood: lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61K 40/11
Characterised by the cell type used: t-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer…
A61K 40/32
Characterised by the recombinant expression of specific molecules in the cells of the immune system: t-cell receptors [TCR]

Family

No related US applications are recorded in the indexed filing history.

Timeline

Citations

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