Salt and crystal form of cycloalkene compound, and preparation method therefor and use thereof
AssigneesJiangsu Hansoh Pharmaceutical Group Co., Ltd., Shanghai Hansoh Biomedical Co., Ltd.
InventorsShiyi YANG, Wei XU, Linsong GUO
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Abstract
A salt and a crystal form of a cycloalkene compound, and a preparation method therefor and the use thereof. Specifically, a salt and a crystal form of a compound as represented by general formula (I), a preparation method, and a pharmaceutical composition comprising a therapeutically effective amount of the salt, and the use thereof as a regulator in the preparation of a drug for treating metabolic diseases and related diseases.
Claims20
A base salt of a compound as represented by general formula (I) or a stereoisomer thereof, wherein the compound has a structure as follows:
- wherein:
- each R1 is independently selected from hydrogen, deuterium, fluorine, chlorine, cyano, C1-3 alkyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 deuteroalkoxy or C1-3 haloalkoxy;
- each R2 is independently selected from hydrogen, deuterium, fluorine, chlorine, cyano, C1-3 alkyl, C1-3 deuteroalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 deuteroalkoxy or C1-3 haloalkoxy;
- each R3 is independently selected from hydrogen, deuterium or halogen;
- M1 is N or CH;
- W2 is N or CH;
- x, y and z are each independently 0, 1 or 2;
- wherein the base is an organic base or an inorganic base, and the organic base is selected from diethylamine, diethanolamine, triethylamine, triethanolamine, choline hydroxide, tromethamine, meglumine, N-hydroxyethylmorpholine, piperazine, N-hydroxyethylpyrrolidine, N,N-dibenzylethylenediamine, 2-diethylaminoethanol, ethanolamine, betaine, L-arginine, lysine, phenethylbenzylamine, benzathine penicillin, dimethylaminoethanol, imidazole or a mixture thereof;
- and the inorganic base is selected from sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, zinc hydroxide, ammonia water or a mixture thereof.
A pharmaceutical composition comprising a therapeutically effective amount of the base salt or the crystal form thereof of the compound or the stereoisomer thereof according to 1, and one or more pharmaceutically acceptable carriers, diluents or excipients.
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Dependencies are inferred from the claim text.