Systems and method of histotripsy diabetes therapy

A system for applying histotripsy therapy, comprising:

• an acoustic coupling assembly configured for placement on a patient;
• a therapy transducer configured to emit an ultrasound signal and generate a bubble cloud at a focal point of the therapy transducer, wherein the therapy transducer is configured to acoustically couple to a duodenum of the patient via the acoustic coupling assembly and fluid within the duodenum of the patient;
• and
• an application stored in a memory and when executed by a processor of a computing device cause the computing device to:
• receive images of the duodenum of the patient;
• define an inner layer of the duodenum;
• define a therapy cylinder;
• define a plurality of bubble cloud locations matching a periphery of the therapy cylinder;
• and
• robotically drive the therapy transducer to a position and orientation where a focal point of the therapy transducer matches the bubble cloud locations;
• and
• apply histotripsy therapy from the therapy transducer to form a bubble cloud at each of the defined bubble cloud locations.