Composition and use thereof

Abstract

The present disclosure provides a cell-derived extracellular vesicle with reduced transplant rejection and having bioactivities against at least one disease selected from the group consisting of kidney diseases, peripheral arterial diseases (PAD), cerebral infarction, pulmonary hypertension (PHD), spinal cord ischemia, non-occlusive mesenteric ischemia, ocular ischemic syndrome, fibrosis, and inflammatory diseases. A composition for use in treating at least one disease selected from the group consisting of kidney diseases, peripheral arterial diseases (PAD), cerebral infarction, pulmonary hypertension (PHD), spinal cord ischemia, non-occlusive mesenteric ischemia, ocular ischemic syndrome, fibrosis, and inflammatory diseases includes an extracellular vesicle of a regenerative cell population induced from a biological sample-derived mononuclear cell or a culture thereof.

Dependencies are inferred from the claim text.