Nutritional Supplement Compositions and Methods for Enhancing Biological Functions

A nutritional supplement composition, comprising:

• nicotinamide adenine dinucleotide in the form of NADH, NAD+, or a combination thereof;
• and
• pyrroloquinoline quinone,
• wherein the nicotinamide adenine dinucleotide and the pyrroloquinoline quinone are present in the nutritional supplement composition at a weight ratio from about 1:40 to about 1:2.

A nutritional supplement composition, comprising:

• a methylthioninium salt;
• urolithin A;
• pyrroloquinoline quinone;
• and
• methylated vitamin B12, nicotinamide adenine dinucleotide in the form of NADH, NAD+, or a combination thereof,
• wherein the nutritional supplement composition has a methylthioninium salt to urolithin A weight ratio from about 1:600 to about 1:4, a methylthioninium salt to pyrroloquinoline quinone weight ratio from about 1:20 to about 50:1, a methylthioninium salt to methylated vitamin B12 weight ratio from about 1:20 to about 50:1 if present, and a methylthioninium salt to nicotinamide adenine dinucleotide weight ratio from about 2:5 to about 200:1 if present.

A method of enhancing weight loss or supporting long-term weight management, comprising:

• orally co-administering a GLP-1 agonist;
• and
• a nutritional supplement composition including:
• a methylthioninium salt,
• urolithin A, and
• pyrroloquinoline quinone, and
• wherein the nutritional supplement composition has a methylthioninium salt to urolithin A weight ratio from about 1:600 to about 1:4, and a methylthioninium salt to pyrroloquinoline quinone weight ratio from about 1:20 to about 50:1.

A combination therapy, comprising co-administering two or more nutritional supplement compositions within a single day to a subject, the two or more nutritional supplement compositions including:

• a first nutritional supplement composition including:
• from about 85 wt % to about 98 wt % liquid carrier, from about 0.5 wt % to about 5 wt % of a mineral blend, from about 0.25 wt % to about 3 wt % methylated vitamin B12, and from about 0.25 wt % to about 3 wt % vitamin C, wherein the mineral blend includes sodium, calcium, magnesium, potassium, and silicon each being independently present in the form of a mineral salt, a mineral oxide, or a mineral chloride;
• a second nutritional supplement composition including:
• nicotinamide adenine dinucleotide in the form of NADH, NAD+, or a combination thereof, and
• pyrroloquinoline quinone,
• wherein the second nutritional supplement composition has a nicotinamide adenine dinucleotide to pyrroloquinoline quinone weight ratio from about 1:40 to about 1:2;
• a third nutritional supplement composition including:
• a methylthioninium salt,
• urolithin A, and
• pyrroloquinoline quinone,
• wherein the third nutritional supplement composition has a methylthioninium salt to urolithin A weight ratio from about 1:600 to about 1:4 and a methylthioninium salt to pyrroloquinoline quinone weight ratio from about 1:20 to about 50:1;
• a fourth nutritional supplement composition, including:
• a methylthioninium salt,
• caffeine, and
• L-theanine,
• wherein the fourth nutritional supplement composition has a methylthioninium chloride to the caffeine weight ratio from about 1:75 to about 1:4, a methylthioninium chloride to the L-theanine weight ratio from about 1:200 to about 1:10, and a caffeine to the L-theanine weight ratio from about 1:5 to about 1:1.