Back to results
US 2026/0217919 A1Published application
Modified triblock copolymer compounds and methods of use thereof
AssigneeRoche Sequencing Solutions, Inc.
InventorsPeter Crisalli, Hannes Kuchelmeister, Cezar Spiridon, Jannik Wagner
Life of this patent
Estimating the term…
Abstract
This application discloses triblock copolymers (TBC) molecules with modified chemical headgroup moieties. The headgroup moieties comprise azide, triazole, and other chemical moieties that make the TBC molecules useful as components in polymersome, vesicle, and membrane compositions, such as synthetic membranes used in nanopore sequencing devices. The application also discloses methods of preparing the modified TBC molecules and methods of use.
Claims9
A triblock copolymer compound of formula:
- wherein
- R1 is an azide, or terminal head group comprising a triazole;
- PMOXA is a poly(2-methyl-2-oxazoline) subunit;
- PDMS is a poly(dimethylsiloxane) subunit;
- R2 is —OH, an azide, or a terminal head group comprising a triazole;
- and
- m is 4 to 20, and n is 20 to 60.
4 more elements
A method for synthesizing a triblock copolymer compound of formula
- R1 is an azide;
- R2 is —OH, an azide;
- PMOXA is a poly(2-methyl-2-oxazoline) subunit;
- PDMS is a poly(dimethylsiloxane) subunit;
- and
- m is 4 to 20, and n is 20 to 60;
- the method comprising:
- (a) providing a compound of formula
- wherein
- A and RB are 2-methyl-2-oxazolinium triflate groups;
- (b) dissolving compound of (a) in acetonitrile and mixing with sodium azide at a ratio of 1 equivalent of compound of (a) to 70 equivalents of sodium azide for 45 h at 80° C. under inert atmosphere;
- and
- (c) cooling to RT, filtering off unreacted sodium azide, and evaporating solvent.
10 more elements
Dependencies are inferred from the claim text.