Monoclonal antibody specifically binding to cathepsin z, and use thereof

A monoclonal antibody comprising any heavy chain variable region and light chain variable region selected from a group consisting of 1) to 9) and specifically binding to cathepsin Z, or an antigen-binding fragment thereof:

• 1) a heavy chain variable region comprising a CDR1 region represented by SEQ ID NO:
• 1, a CDR2 region represented by SEQ ID NO:
• 2 and a CDR3 region represented by SEQ ID NO:
• 3 and a light chain variable region comprising a CDR1 region represented by SEQ ID NO:
• 4, a CDR2 region represented by SEQ ID NO:
• 5 and a CDR3 region represented by SEQ ID NO:
• 6;
• 2) a heavy chain variable region comprising a CDR1 region represented by SEQ ID NO:
• 7, a CDR2 region represented by SEQ ID NO:
• 8 and a CDR3 region represented by SEQ ID NO:
• 9, and a light chain variable region comprising a CDR1 region represented by SEQ ID NO:
• 10, a CDR2 region represented by SEQ ID NO:
• 11 and a CDR3 region represented by SEQ ID NO:
• 12;
• 3) a heavy chain variable region comprising a CDR1 region represented by SEQ ID NO:
• 13, a CDR2 region represented by SEQ ID NO:
• 14 and a CDR3 region represented by SEQ ID NO:
• 15, and a light chain variable region comprising a CDR1 region represented by SEQ ID NO:
• 16, a CDR2 region represented by SEQ ID NO:
• 17 and a CDR3 region represented by SEQ ID NO:
• 18;
• 4) a heavy chain variable region comprising a CDR1 region represented by SEQ ID NO:
• 19, a CDR2 region represented by SEQ ID NO:
• 20 and a CDR3 region represented by SEQ ID NO:
• 21, and a light chain variable region comprising a CDR1 region represented by SEQ ID NO:
• 22, a CDR2 region represented by SEQ ID NO:
• 23 and a CDR3 region represented by SEQ ID NO:
• 24;
• 5) a heavy chain variable region comprising a CDR1 region represented by SEQ ID NO:
• 25, a CDR2 region represented by SEQ ID NO:
• 26 and a CDR3 region represented by SEQ ID NO:
• 27, and a light chain variable region comprising a CDR1 region represented by SEQ ID NO:
• 28, a CDR2 region represented by SEQ ID NO:
• 29 and a CDR3 region represented by SEQ ID NO:
• 30;
• 6) a heavy chain variable region comprising a CDR1 region represented by SEQ ID NO:
• 31, a CDR2 region represented by SEQ ID NO:
• 32 and a CDR3 region represented by SEQ ID NO:
• 33, and a light chain variable region comprising a CDR1 region represented by SEQ ID NO:
• 34, a CDR2 region represented by SEQ ID NO:
• 35 and a CDR3 region represented by SEQ ID NO:
• 36;
• 7) a heavy chain variable region comprising a CDR1 region represented by SEQ ID NO:
• 37, a CDR2 region represented by SEQ ID NO:
• 38 and a CDR3 region represented by SEQ ID NO:
• 39, and a light chain variable region comprising a CDR1 region represented by SEQ ID NO:
• 40, a CDR2 region represented by SEQ ID NO:
• 41 and a CDR3 region represented by SEQ ID NO:
• 42;
• 8) a heavy chain variable region comprising a CDR1 region represented by SEQ ID NO:
• 43, a CDR2 region represented by SEQ ID NO:
• 44 and a CDR3 region represented by SEQ ID NO:
• 45, and a light chain variable region comprising a CDR1 region represented by SEQ ID NO:
• 46, a CDR2 region represented by SEQ ID NO:
• 47 and a CDR3 region represented by SEQ ID NO:
• 48;
• and
• 9) a heavy chain variable region comprising a CDR1 region represented by SEQ ID NO:
• 49, a CDR2 region represented by SEQ ID NO:
• 50 and a CDR3 region represented by SEQ ID NO:
• 51, and a light chain variable region comprising a CDR1 region represented by SEQ ID NO:
• 52, a CDR2 region represented by SEQ ID NO:
• 53 and a CDR3 region represented by SEQ ID NO:
• 54.