Compositions useful for modulating splicing

A compound of Formula (I), or a pharmaceutically acceptable salt thereof:

• wherein,
• R21 is thiophenyl, which is unsubstituted or substituted with 1, 2, or 3, independently selected R1A groups;
• each R1A is independently selected from halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 alkoxy, —C(═O)OH, —C(═O)C1-6 alkyl, —C(═O)C1-6 haloalkyl, and —C(═O)C1-6 alkoxy
• R23 is selected from the group consisting of H, azido, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 heteroalkyl, —(C1-6 alkylene)-C3-10 cycloalkyl, —(C1-6 alkylene)-4-10 membered heterocycloalkyl, —(C1-6 heteroalkylene)-C3-10 cycloalkyl, —(C1-6 heteroalkylene)-4-10 membered heterocycloalkyl, C3-10 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, ORa3, SRa3, C(═O)Rb3, C(═O)ORb3, NRc3Rd3, C(═O)NRc3Rd3, —OC(═O)NRc3Rd3, NRc3C(═O)Rb3, NRc3C(═O)ORb3, NRc3C(═O)NRc3Rd3, NRc3S(═O)2Rb3, NRc3S(═O)2NRc3Rd3, S(O)NRc3Rd3, and S(O)2NRc3Rd3, wherein the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 heteroalkyl, C1-6 alkylene, C1-6 heteroalkylene, C3-10 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl are each optionally substituted by 1, 2, 3, or 4 independently selected R20 groups;
• R24 is selected from the group consisting of H, azido, halo, CN, NO2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, ORa4, C(═O)Rb4, C(═O)ORb4, NRc4Rd4, C(═O)NRc4Rd4, —OC(═O)NRc4Rd4, NRc4C(═O)Rb4, NRc4C(═O)ORb4, NRc4C(═O)NRc4Rd4, NRc4S(═O)2Rb4, NRc4S(═O)2NRc4Rd4, S(O)NRc4Rd4, and S(O)2NRc4Rd4, wherein the C1-6 alkyl, C3-10 cycloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl are each optionally substituted by 1, 2, 3, or 4 independently selected R20 groups;
• each Ra3, Rb3, Rc3, Rd3, Ra4, Rb4, Rc4, and Rd4, is independently selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 hydroxyalkyl, C1-6 haloalkyl, C1-6 alkoxy, —(C1-6 alkylene)-C1-6 alkoxy, C3-10 cycloalkyl, —(C1-6 alkylene)-C3-10 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, wherein the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, —(C1-6 alkylene)-C3-10 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl are each optionally substituted by 1, 2, 3, or 4 independently selected R20 groups;
• or Rc3 and Rd3 together with the N atom to which they are connected, come together to form a 5-10 membered heteroaryl or 4-10 membered heterocycloalkyl ring, each optionally substituted by 1, 2, 3, or 4 independently selected R20 groups;
• or Rc4 and Rd4 together with the N atom to which they are connected, come together to form a 5-10 membered heteroaryl or 4-10 membered heterocycloalkyl ring, each optionally substituted by 1, 2, 3, or 4 independently selected R20 groups;
• and
• each R20 is independently selected from the group consisting of OH, SH, CN, NO2, halo, oxo, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, C1-4 cyanoalkyl, C1-4 hydroxyalkyl, C1-4 alkoxy, —(C1-4 alkyl)-(C1-4 alkoxy), —(C1-4 alkoxy)-(C1-4 alkoxy), C1-4 haloalkoxy, C3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-6 membered heterocycloalkyl, amino, C1-4 alkylamino, di(C1-4 alkyl)amino, carbamyl, C1-4 alkylcarbamyl, di(C1-4 alkyl) carbamyl, carbamoyl, C1-4 alkylcarbamoyl, di(C1-4 alkyl) carbamoyl, C1-4 alkylcarbonyl, C1-4 alkoxycarbonyl, C1-4 alkylcarbonylamino, C1-4 alkylsulfonylamino, aminosulfonyl, C1-4 alkylaminosulfonyl, di(C1-4 alkyl)aminosulfonyl, aminosulfonylamino, C1-4 alkylaminosulfonylamino, di(C1-4 alkyl)aminosulfonylamino, aminocarbonylamino, C1-4 alkylaminocarbonylamino, di(C1-4 alkyl)aminocarbonylamino, and amidinyl.