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US 2026/0217715 A1Published application
An efficient process for the synthesis of theacrine
AssigneeFertis India Pvt Ltd
InventorsRahul Raju KANUMURU, Shaji George KOCHUMALAYIL, Ravikumar SURANENI, Mohanarao VANA MURALI
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Abstract
The present invention provides an industrial process for the synthesis of Theacrine with high purity and quality.
Claims19
A process for the preparation of Theacrine (2) in an efficient manner which process comprises
- a) reacting compound(s) of formula I with a methylating agent in presence of base and solvent to obtain Theacrine (2);
- and optionally purifying the Theacrine from methanol,
- wherein, R1 is hydrogen or methyl;
- R2 is hydrogen or absent and;
- R3 is methyl, dashed bond can be single or double bond,
- with the proviso;
- when the dashed bond is a double bond to oxygen,
- then R1 and R2 is hydrogen and R3 is absent
- with the proviso;
- when the dashed bond is a single bond to oxygen,
- then, R1 and R3 are methyl and R2 is absent.
8 more elements
A process for preparation of Theacrine 2 which process comprises reacting mixtures of compound(s) of formula 2 and formula 3 with Trimethyl phosphate in presence of a solvent and optionally in presence of potassium carbonate base at 150° C. to obtain Theacrine (2).
Dependencies are inferred from the claim text.