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US 2026/0217661 A1Published application
Treatments for pain
OwnerKeith MENEARinventor
Life of this patent
Estimating the term…
Abstract
The Application describes new SOS1 inhibitors for use in the treatment of pain and cancer.
Claims14
A Compound of formula (I)
- Or a pharmaceutically acceptable salt or solvate thereof, wherein:
- X is N or CR9
- R1 is selected from:
- O—C1-6 alkyl
- O—R10
- O—C1-6 alkyl-R10
- R11
- R2 is selected from
- R3 is H or NH2
- R4 is CF3, CF2CH2OH, CN
- R5 is halo
- R6 is H
- R7 is H
- R8 is Ph, ortha substituted by CH2NHCH3
- R9 is H, OCH3, F and CN
- R10 is 4-6 membered saturated heterocycle containing 1-2 heteroatoms, selected from O, N & S wherein S may also include SO and SO2 moieties, said heterocycle may also be optionally substituted by C(O)C1-6 alkyl, S(O)2C1-6 alkyl and C1-6 alkyl,
- R11 is 4-6 membered saturated, or partially saturated heterocycle containing 1-2 heteroatoms, selected from O, N & S wherein S may also include SO and SO2 moieties, said heterocycle may also be optionally substituted by 1-2 groups selected from C(O)C1-6alkyl, N C(O)C1-6 alkyl, OH, an ether linkage to form a bi-cycle and C1-6 alkyl.
14 more elements
A compound according to any preceeding claim wherein X is N or CR9, wherein R9 is H.
A compound according to any preceeding claim wherein X is CR9, wherein R9 is H.
Dependencies are inferred from the claim text.