Pou5f1b inhibitors
AssigneeEcole Polytechnique Federale De Lausanne (Epfl)
InventorsLaia SIMÓ RIUDALBAS, Didier TRONO, Laurence GOUZI ABRAMI, Gisou VAN DER GOOT, Sandra OFFNER
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Abstract
The invention provides an agent modulating the expression and/or activity of i) the POU5F1B protein, a fragment or variant thereof, ii) an mRNA encoding POU5F1B, a fragment or variant thereof and/or iii) the POU5F1B gene. Preferably, the agent is for use in the treatment and/or prevention of a disease linked to the expression of POU5F1B in a subject in need thereof.
Claims27
A method for treating and/or preventing a disease linked to the expression of POU5F1B in a subject in need thereof, the method comprising administering a therapeutically effective amount of an agent that modulates the expression and/or activity of i) the POU5F1B protein, a fragment or variant thereof, ii) an mRNA encoding POU5F1B, a fragment or variant thereof, and/or iii) the POU5F1B gene.
A gene delivery vector comprising a nucleic acid encoding an agent that modulates the expression and/or activity of i) the POU5F1B protein, a fragment or variant thereof, ii) an mRNA encoding POU5F1B, a fragment or variant thereof, and/or iii) the POU5F1B gene,
- wherein the agent is an oligonucleotide comprising an siRNA, an shRNA, an snRNA, an siRNA capable of interfering the expression of short hairpin (sh), a guide RNA, a piRNA, an antisense oligonucleotide, or a combination of one or more thereof.
A method for diagnosing a disease linked to the expression of POU5F1B in a biological sample of a subject, the method comprising:
- i) detecting, directly or indirectly, the expression and/or activity of the POU5F1B protein, a fragment or variant thereof, or
- ii) detecting, directly or indirectly, the presence of an mRNA encoding POU5F1B, a fragment or variant thereof,
- wherein the expression and/or activity of the POU5F1B protein, a fragment or variant thereof or the presence of an mRNA encoding the POU5F1B protein, a fragment or variant thereof indicates that the subject has or is determined to have a disease linked to the expression of POU5F1B.
(canceled)
Dependencies are inferred from the claim text.