Compositions and methods for targeting and treating tumor
AssigneeJiangsu Code Biomedical Technology Co., Ltd.
InventorsShiyang Pan, Jian Xu, Lei Zhang, Yue Pan
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Abstract
Nanoparticles encapsulating core particles with attached photothermal agents, and therapeutic agents. The methods of imaging a tumor tissue and/or treating a subject suffering from tumor with the nanoparticles provided herein.
Claims43
A composition comprising:
- a photothermal agent, and one or more core particles,
- wherein the photothermal agent and the core particles are encapsulated in a nanoparticle made from a biodegradable material.
The composition of any one of the preceding claims, wherein the core particles are surface-modified for the attachment of the photothermal agent.
The composition of any one of the preceding claims, wherein the core particles have a diameter of about 10 nm to about 40 nm.
The composition of any one of the preceding claims, wherein the composition comprises about 1 to about 10 core particles.
The composition of any one of the preceding claims, wherein the photothermal agent is selected from the group consisting indocyanine green (ICG), polydopamine, polyaniline (PANI), and polypyrrole (PPY).
The composition of any one of the preceding claims, further comprising a therapeutic agent, wherein the therapeutic agent is encapsulated in the nanoparticle.
The composition of any of the preceding claims, wherein the therapeutic agent is an anti-cancer therapeutic agent.
The composition of any one of the preceding claims, wherein the composition further comprises a tumor-targeting molecule attached to the surface of the nanoparticle.
The composition of any one of the preceding claims, wherein the diameter of the nanoparticle is about 70 nm to about 120 nm.
A method of producing the composition of any of the preceding claims, wherein the method comprises:
- (a) contacting one or more core particles with the photothermal agent, thereby attaching the photothermal agent to the surface of the core particles;
- (b) preparing a double emulsion comprising the biodegradable material;
- and
- (c) contacting the product of step (a) with the double emulsion prepared in step (b), thereby producing the nanoparticles encapsulating the core particles;
- thereby producing the composition.
Dependencies are inferred from the claim text.