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US 2026/0216305 A1Published application
Tau peptide immunogen constructs
AssigneeVaxxinity, Inc.
InventorsJustin Boyd, Jean-Cosme Dodart
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Abstract
The present disclosure is directed to individual peptide immunogen constructs targeting portions of the Tau protein for the treatment and/or prevention of tauopathies. The present disclosure is also directed to compositions containing the peptide immunogen constructs, methods of making and using the peptide immunogen constructs, and antibodies produced by the peptide immunogen constructs.
Claims25
1-23. (canceled)
A Tau peptide immunogen construct comprising:
- a B cell epitope comprising SEQ ID NO:
- 2 or a functional analogue thereof;
- and
- a heterologous T helper cell epitope selected from SEQ ID NOs:
- 138-166;
- wherein the B cell epitope is covalently linked to the heterologous T helper cell epitope directly or through a heterologous spacer.
3 more elements
Dependencies are inferred from the claim text.