Alpp-specific variant antigen binding molecules
OwnerGraham John COTTON, Paul Richard TRUMPER +3inventors
InventorsGraham John COTTON, Paul Richard TRUMPER, Estelle MCLEAN, Mark WAPPETT, Aaron CRANSTON
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Abstract
The present invention relates to alkaline phosphatase, placental type (ALPP) and/or alkaline phosphatase, germ cell type (ALPPL2) specific antigen binding molecules and associated fusion proteins and conjugates and methods of producing the same. In a further aspect, the present invention relates to conjugated single domain antibodies (VHH domains).
Claims57
An alkaline phosphatase, placental type (ALPP) and/or alkaline phosphatase, germ cell type (ALPPL2) specific antigen binding molecule comprising an amino acid sequence represented by the formula (I):
- wherein
- FW1 is a framework region;
- CDR1 is a CDR sequence;
- FW2 is a framework region;
- CDR2 is a CDR sequence;
- FW3 is a framework region;
- CDR3 is a CDR sequence;
- FW4 is a framework region.
The ALPP and/or ALPPL2 specific antigen binding molecule of any preceding claim, having an amino acid sequence of any one of SEQ ID NOs:
- 17, 28, 30, 31 or 34.
A recombinant fusion protein comprising the ALPP and/or ALPPL2 specific antigen binding molecule of any preceding claim.
An engineered ALPP and/or ALPPL2 monomer, wherein the engineered ALPP and/or ALPPL2 monomer is engineered to be capable of forming a covalent link with a further engineered ALPP and/or ALPPL2 monomer.
A bi-paratopic alkaline phosphatase, placental type (ALPP) and/or alkaline phosphatase, germ cell type (ALPPL2) specific antigen binding molecule.
Dependencies are inferred from the claim text.