Inhibition of zbtb7a
AssigneeIcahn School of Medicine at Mount Sinai
InventorsSasha Fulton, Ian S. Maze
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Abstract
Provided herein are compositions and methods for treating various disorders by inhibition of zinc finger and BTB domain-containing protein 7A (ZBTB7A). The compositions and methods provided herein may be useful for treating psychiatric disorders, for example, Major Depressive Disorder (MDD), Bipolar Disorder, Dysthymia, Post-traumatic Stress Disorder (PTSD), Sub-stance-induced mood disorder, Generalized Anxiety Disorder, Social Phobia, Panic Disorder, or Mood Disorder Due to a General Medical.
Claims24
A method of treating a psychiatric disorder, the method comprising:
- identifying a subject as having the psychiatric disorder;
- and
- administering to the subject an effective dose of a composition that reduces levels of ZBTB7A in cells of the subject.
A method of treating a psychiatric disorder, the method comprising administering to a subject having the psychiatric disorder an effective dose of a composition comprising a recombinant adeno-associated virus (rAAV) comprising a ZBTB7A-targeting inhibitory RNA-encoding DNA.
A recombinant adeno-associated virus comprising a ZBTB7A-targeting inhibitory RNA-encoding DNA comprising a sequence selected from the group consisting of SEQ ID NO:
- 3;
- SEQ ID NO:
- 4;
- SEQ ID NO:
- 5;
- SEQ ID NO:
- 6;
- SEQ ID NO:
- 7;
- SEQ ID NO:
- 8;
- SEQ ID NO:
- 9;
- or SEQ ID NO:
- 10.
Dependencies are inferred from the claim text.