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AssigneeDebreceni Egyetem
InventorsPéter NAGY, József BALLA, Dorottya GARAI
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Treatment of Myeloperoxidase-positive ANCA-associated vasculitis with H2S releasing compounds The invention is related to hydrogen sulfide (H2S) releaser compounds and compositions for use in the treatment of myeloperoxidase (MPO) induced neutrophil mediated tissue damage, in particular positive antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV), including MPO granulomatosis with polyangiitis (Wegener's granulomatosis), eosinophilic granulomatosis with polyangiitis (EGPA; formerly called Churg-Strauss syndrome), microscopic polyangiitis (MPA) and various forms of the disease in various organs, like the kidney and the lung.
A H2S donor compound for the treatment of antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) in a mammalian patient having AAV of the myeloperoxidase-ANCA (MPO-ANCA) serotype, preferably said AAV being a myeloperoxidase (MPO) autoantigen positive AAV wherein said subject has an increased MPO-specific ANCA level.
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