(n-alkyldihydrol-2h-oxazinyl)-cannabidiol as anti-proliferative agent and process for preparation thereof

A process for the synthesis of ring annulated cannabidiol analogue compound of Formula I,

• wherein, both A and B rings are simultaneously present or at least one of the ring is present;
• R is alkyl;
• R1 is independently selected from alkyl, aryl, heteroaryl, or cycloalkyl;
• wherein the alkyl, aryl is optionally substituted with one or more groups, independently selected from the group consisting of —F, alkyl, —O-haloalkyl, aryl, and heterocyclyl;
• and
• R2 is H
• comprising the steps of:
• i. coupling of fragment II and fragment III in the presence of an aldehyde IV at a temperature in the range of 25-30° C., for a period in the range of 13-16 hours optionally in presence of a solvent
• and
• ii. purifying the obtained compound of formula I.