US 2026/0216144 A1 · TARGETING MB2 OF THE MYC ONCOGENE AND ITS INTERACTION WITH TRRAP IN CANCER

Abstract

Provided are methods and compositions for identifying inhibitors of an interaction between the oncogenic transcription factor MYC and its cofactor TRRAP. The methods involve both cell-based and in vitro approaches for probing an interaction between MYC and TRRAP and for identifying inhibitors of a MYC-TRRAP interaction. Also provided are compounds for use as inhibitors of an interaction between MYC and TRRAP, and methods for developing a cancer therapeutic from such compounds, including methods for derivatizing such inhibitors and for testing the inhibitors and derivatized inhibitors for an ability to treat cancer in a subject. The methods, compounds, and compositions provided herein can provide various advantages, such as a means to target the oncogenic transcription factor MYC in cancer.

Claims17

Dependent claims

A method for identifying a chemical compound which inhibits the binding interaction between MYC transcription factor and Transformation/Transcription Domain-Associated Protein (TRRAP), comprising:

a) forming a MYC:TRRAP complex having a MYC:TRRAP binding interaction;
b) directly and/or indirectly detecting the MYC:TRRAP complex and/or the MYC:TRRAP binding interaction to determine a baseline measurement for the MYC:TRRAP complex and/or the MYC:TRRAP binding interaction;
c) introducing a compound prior to or after forming a MYC:TRRAP complex having a MYC:TRRAP binding interaction;
and
d) determining an absence or a reduction of the MYC:TRRAP complex and/or the MYC:TRRAP binding interaction after the chemical compound has been introduced compared to the baseline measurement, wherein the absence or the reduction of the MYC:TRRAP complex and/or the MYC:TRRAP binding interaction indicates that the chemical compound is an inhibitor of the binding interaction between MYC and TRRAP.

2 more elements

Dependencies are inferred from the claim text.

Targeting mb2 of the myc oncogene and its interaction with trrap in cancer

Life of this patent

Targeting mb2 of the myc oncogene and its interaction with trrap in cancer

Life of this patent

Abstract

Claims17