Pyrrole compounds

A compound of Formula (I), or a pharmaceutically acceptable salt thereof, having the structure:

• wherein:
• R1 is an unsubstituted C2 alkynyl;
• R2 is an unsubstituted C1-4 alkyl;
• R3 is selected from the group consisting of a substituted C1-4 alkyl and an unsubstituted C1-4 hydroxyalkyl, wherein the substituted C1-4 alkyl is substituted with one or more substituents independently selected from the group consisting of a phosphate, an O-linked α-amino acid and an O-carboxy;
• or
• R1 is an unsubstituted C2 alkenyl or an unsubstituted C2 alkynyl;
• R2 and R3 are taken together along with the carbon to which R2 and R3 are attached to form an unsubstituted or a substituted monocyclic C3-4 cycloalkyl or an unsubstituted or a substituted monocyclic 3-4 membered heterocyclyl, wherein when the C3-4 cycloalkyl and the 3-4 membered heterocyclyl are substituted, the C3-4 cycloalkyl and the 3-4 membered heterocyclyl are independently substituted with 1 or 2 substituents independently selected from the group consisting of halogen and hydroxy;
• R4 and R5 are each an unsubstituted C1-4 alkyl;
• R6 is an unsubstituted C1-4 alkyl;
• X1 is CRA;
• RA is halogen;
• R7a, R7c and R7d are each hydrogen;
• R7b is an unsubstituted C1-4 haloalkyl or cyano;
• and
• R8 is-CH2OC(═O)-(an unsubstituted C1-4 alkyl), —CH2OC(═O)—O(an unsubstituted C1-4 alkyl), —CH2-(α-amino acid) or —CH2-phosphate.