Quaternary ammonium compounds (qacs) and process for preparation thereof
AssigneesRajaram SAMANT, Manoj TONGRA
InventorsRajaram SAMANT, Manoj TONGRA, Jotiram PALKAR
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Abstract
The present invention disclosed herein relates to a quaternary ammonium compound represented by Formula-I and simple, viable process for preparation thereof. Particularly, the present invention relates to novel therapeutically active quaternary ammonium carboxylate compounds. The compounds of Formula-I are useful for treating metabolic, neuropsychiatric, neurodevelopmental conditions, pregnancy health, fetal growth, cognitive development.
Claims10
A quaternary ammonium carboxylate compound of Formula I:
- wherein R1, R2 and R3 are same or independently selected from the group consisting of H, OH, (C1-C9)alkyl, alkylene, alkyne, (C1-C9)-O—, heterocyclic group, —COOR, halide,
- substituted or unsubstituted cycloalkyl, aryl and arylalkyl;
- wherein X is
- wherein R4 is selected from the group consisting of H, OH, (C1-C9)alkyl, alkylene, alkyne, aryl, aralkyl, (C3-C8) cycloalkyl, (C1-C9)-O—, heterocyclic group, —COOR, halide and
- wherein R is lower alkyl;
- wherein R5 is selected from the group consisting of H, OH, alkyl, alkoxy, aryl, biphenyl, heterocyclic and cycloalkyl compounds.
A process for preparation of a compound of Formula-I, comprising:
- i) dehalogenation quaternary ammonium compound of Formula-I in presence of an organic solvent at warm condition to obtain a crude quaternary ammonium carboxylate compound;
- ii) purification of the crude quaternary ammonium carboxylate compound at a temperature in the range of 10° C.-130° C. to obtain high yield and purity of the compound of Formula-I.
A composition comprising a compound of Formula-I and at least one pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.