Selective Serotonin Receptor Modulators and Methods of Making and Using the Same

A method of treating a neurological disorder associated with abnormal cortical electrical activity in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of at least one compound of Formula I:

• wherein
• X and Y are each hydrogen;
• W1 is selected from O, S, S(O), SO2, Se, Se(O), and SeO2;
• W2 is C(R3)(R3′);
• Z4 is selected from N and CR4;
• Z5 is selected from N and CR5;
• Z6 is selected from N and CR6;
• Z7 is selected from N and CR7;
• R2 is selected from optionally substituted C1-C8 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted aryl, optionally substituted heteroaryl;
• R3 and R3′ are each, independently, selected from hydrogen and deuterium;
• R4, R5, R6, and R1 are each independently selected from hydrogen, deuterium, and halo;
• represents an optionally substituted cycloalkanyl, wherein the is a single bond and wherein Rx and Rw are each, independently, selected from hydrogen, deuterium, and halo;
• and salts, solvates, hydrates, prodrugs, and enantiomers thereof,
• wherein the administration reduces pathological spike-and-wave discharges (SWDs) as measured by electroencephalography (EEG).