Novel ionizable lipid compounds for nucleic acid delivery

A compound of Formula I

• or a salt or isomer thereof, wherein
• each m is independently an integer from 4-13;
• each n is independently an integer from 1-3;
• each R1 is independently selected from C1-C5 alkyl, C2-C5 alkenyl, or C2-C5 alkynyl, wherein alkyl, alkenyl, or alkynyl is linear or branched;
• each R2 and R3 is independently selected from C1 to C14 alkyl;
• each R6 is independently selected from H,
• each M1 and M2 is independently selected from —C(O)O— and —OC(O)—, wherein at least one of M1 or M2 is —C(O)O—;
• each Q is selected from —O— or —NH—;
• and each G is —(CR4R5)k—;
• wherein each k is selected from an integer from 2-5,
• and each R4 and R5 is independently selected from H, and C1-C3 alkyl.